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KMID : 0376219840210030539
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Chonnam Medical Journal
1984 Volume.21 No. 3 p.539 ~ p.551
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The Fine Structure and Innervation of the Pancreatic Islets of the Mongolian gerbil
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Abstract
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The fine structure and innervation of the pancreatic islets of the Mongolian gerbil were studied by electron microscopy.
The pancreatic islet cells could be distinguished as A, B, and D cells according to the character of their granules. The diameter of A cell granules was 190nm and the core of them was electron-dense and centrally located. The B cell granules were 240 nm in diameter and the density was variable. The diameter of D cell granules was 120nm and the granules were filled with secretory substances.
Only nonmyelinated nerve fibers were observed to innervate islet cells. Cholinergic and dopaminergic nerve endings were either attached to the innervated cells, or intercalated by thin Schwann cell cytoplasm or embedded into the islet cell. One axon terminal was observed to innervate two or three islet cells, regardless of the cell type.
After administration of 5-hydroxydopamine, the core materials within the vesicles of the adrenergic nerve endings accumulated the osmiophilic substances, while the vesicles of the cholinergic nerve endings remained unchanged.
In the pericapillary space or in the peryphery of islets, Schwann cell-axon complex consisted of axons, nerve endings and Schwann cell investing them and processes of the Schwann cell contacted with islet cells.
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